BioCentury
ARTICLE | Emerging Company Profile

Iambic: Turning AI and automation into a two-year chemistry-to-clinic cycle

San Diego company’s physics-informed algorithms have begun delivering small molecules to the clinic in two years — and attracting partners

November 21, 2025 11:12 PM UTC

Iambic intends to prove that AI-guided chemistry plus high-throughput automation can compress chemistry-to-IND timelines and solve problems traditional methods can’t. Its lead program is off to a strong start in delivering on those goals.

After starting out as Entos Inc. in 2019, the San Diego-based biotech marked its transition from platform developer to therapeutics developer in 2023 by rebranding as Iambic Therapeutics Inc. ...