2025 catalysts: New mechanisms in obesity, neurology, ophthalmology

As the obesity pipeline swells, BioCentury has its sights this year on new mechanisms poised to deliver clinical proof of concept, as well as updates from the field’s leaders and next-gen players with compelling differentiation stories. Below is a selection of these with disclosed readouts in 2025; the list is not comprehensive but reflects programs with disclosed readouts that could be among the year’s highlights, should the data be positive.

The year will also bring crossover between obesity and neurology with GLP-1 data expected in Alzheimer’s disease, and a neuroinflammation-targeting program due to read out in obesity...