ARTICLE | Product Development
LNP innovation: tissue specificity, aided by AI
How LNP companies delivering nucleic acids are cracking the tissue tropism problem, and finding freedom to operate
July 5, 2024 7:19 PM UTC
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The longstanding challenge of getting lipid nanoparticles to the right tissues has limited the nucleic acid delivery modality’s applications, despite their size and immunogenicity advantages. Companies aim to overcome that bottleneck by engineering the particles’ subunits, with some turning to AI to learn the rules dictating tissue tropism, and steer clear of patent thickets. ...